Today’s systems (satellites, aircraft, surface ships, ground vehicles, and subsurface vehicles) have large numbers of electronic components including microprocessors, microcontrollers, sensors, actuators, and internal (onboard) and external (off-board) communication networks. Hardening and securing these systems is currently performed using checklist approaches like the Risk Management Framework (RMF) that derive from decades of information technology best practices. Over the last decade, these techniques have served these industries well and have protected platform operators from harm. However, more sophisticated cyberattacks are challenging the military and industry every day, proving that defense-in-depth solutions are not enough to evade and recover from tomorrow’s adversarial attack.